Phenotypes Associated with This Genotype

Genotype
MGI:5508232

• Allelic Composition: Kras^tm1Bbd/Kras⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:172200 )

• 50% survival at 40 weeks of age following intratracheal instillation of Ad-Cre

premature death ( J:172200 )

• following intratracheal instillation of adenovirus expressing Cre-recombinase (Ad-Cre), 50% of mice die by 40 weeks

neoplasm

increased lung non-small cell carcinoma incidence ( J:172200 )

• mice develop non-small cell lung carcinoma following intratracheal instillation of adenovirus expressing Cre-recombinase (Ad-Cre)

respiratory system

increased lung non-small cell carcinoma incidence ( J:172200 )

• mice develop non-small cell lung carcinoma following intratracheal instillation of adenovirus expressing Cre-recombinase (Ad-Cre)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:172200