Phenotypes Associated with This Genotype

Genotype
MGI:5508895

ht7

• Allelic Composition: Ins2^Akita/Ins2⁺
• Genetic Background: C.B6N-Ins2^Akita

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

albuminuria ( J:198186 )

• 3-fold increase in albumin-to-creatine ratio at 4 months of age, however albuminuria does not persist at 6 months of age

renal/urinary system

albuminuria ( J:198186 )

• 3-fold increase in albumin-to-creatine ratio at 4 months of age, however albuminuria does not persist at 6 months of age

expanded mesangial matrix ( J:198186 )

• mesangial matrix expansion is seen at 4 months of age

glomerulosclerosis ( J:198186 )

• same degree of glomerular injury as in homozygotes at 6 months of age

increased renal glomerular filtration rate ( J:198186 )

• glomerular filtration rate is increased at 6 months of age