Phenotypes Associated with This Genotype

Genotype
MGI:5509206

• Allelic Composition: Tg(HBx)3Yu/0
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:56196 )

• mutants develop hepatocellular carcinoma, with small neoplastic nodules seen by 6 months of age and 64% of mutants showing hepatocellular carcinoma at 11-18 months of age

• overall incidence of hepatic tumors, including grossly identified hepatocellular carcinomas and small neoplastic nodules is 86% from 11-18 months of age

liver/biliary system

abnormal liver morphology ( J:56196 )

• non-neoplastic area of livers show small vacuoles in the cytoplasm and evidence of dysplasia, with mild to moderate pleomorphic nuclei and an increase in nuclear size with clumped chromatin

increased hepatocellular carcinoma incidence ( J:56196 )

• mutants develop hepatocellular carcinoma, with small neoplastic nodules seen by 6 months of age and 64% of mutants showing hepatocellular carcinoma at 11-18 months of age

• overall incidence of hepatic tumors, including grossly identified hepatocellular carcinomas and small neoplastic nodules is 86% from 11-18 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:56196