Phenotypes Associated with This Genotype

Genotype
MGI:5509299

• Allelic Composition: Tg(SNCA*E46K)3Elan/?
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

astrocytosis ( J:200740 )

• astrogliosis is detected in old mice, however microgliosis is not detected

abnormal dopaminergic neuron morphology ( J:200740 )

• age-dependent tyrosine hydroxylase positive fiber degeneration is observed in the striatum

abnormal synapse morphology ( J:200740 )

• some striatal synaptic proteins exhibit prominent alterations

alpha-synuclein inclusion body ( J:200740 )

• accumulation of alpha-synuclein is found in the heart, small intestine, and brain, including the substantia nigra pars compacta neurons

neurodegeneration ( J:200740 )

• age-dependent synaptic degeneration occurs in the cortex and striatum

• age-dependent tyrosine hydroxylase positive fiber degeneration is observed in the striatum

behavior/neurological

impaired coordination ( J:200740 )

♀ • female mice exhibit impaired beam traversal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 1		DOID:0060367	OMIM:168601	J:200740