Phenotypes Associated with This Genotype

Genotype
MGI:5509461

cx2

• Allelic Composition: Sytl1^tm1Tiz/Sytl1^tm1Tiz; Sytl4^tm1Tiz/Sytl4^tm1Tiz
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:200233 )

• beta cells lack docked granules whose lining membrane is directly attached to the plasma membrane and have fewer granules with centers within 300 nm of the plasma membrane compared with wild-type cells

decreased insulin secretion ( J:200233 )

• glucose-stimulated

homeostasis/metabolism

decreased insulin secretion ( J:200233 )

• glucose-stimulated