Phenotypes Associated with This Genotype

Genotype
MGI:5510482

ht9

• Allelic Composition: Ins2^Akita/Ins2⁺
• Genetic Background: involves: C57BL/6NSlc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:200802 )

N • mice exhibit normal insulin sensitivity

decreased insulin secretion ( J:200802 )

• decreased total pancreatic insulin and prolinsulin content

increased circulating glucose level ( J:200802 )

decreased circulating leptin level ( J:200802 )

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:200802 )

• beta cells contain a small number of secretory granules, a tubulovesicular structure comprised of enlarged endoplasmic reticulum, and swelling or disruption of mitochondria

decreased insulin secretion ( J:200802 )

• decreased total pancreatic insulin and prolinsulin content

growth/size/body

decreased body weight ( J:200802 )

behavior/neurological

increased food intake ( J:200802 )