Phenotypes Associated with This Genotype

Genotype
MGI:5510483

cx22

• Allelic Composition: Ins2^Akita/Ins2⁺; Rnf213^tm1.1Akoi/Rnf213^tm1.1Akoi
• Genetic Background: involves: C57BL/6N * C57BL/6NSlc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:200802 )

N • mice exhibit normal insulin sensitivity and insulin plasma levels

decreased insulin secretion ( J:200802 )

• decreased total pancreatic insulin and prolinsulin content that is not as severe as in Ins2^Akita heterozygotes

increased circulating glucose level ( J:200802 )

• not as severe as in Ins2^Akita heterozygotes from 6 to 20 weeks

decreased circulating leptin level ( J:200802 )

impaired glucose tolerance ( J:200802 )

• not as severe as in Ins2^Akita heterozygotes

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:200802 )

• beta cells exhibit mild endoplasmic reticulum enlargement and slight mitochondria swelling that not as severe as in Ins2^Akita heterozygotes

decreased pancreatic beta cell number ( J:200802 )

• not as severe as in Ins2^Akita heterozygotes

decreased insulin secretion ( J:200802 )

• decreased total pancreatic insulin and prolinsulin content that is not as severe as in Ins2^Akita heterozygotes

behavior/neurological

increased food intake ( J:200802 )

• ot as much as in Ins2^Akita heterozygotes

growth/size/body

decreased body weight ( J:200802 )

• at 6 and 9 weeks but not 10 weeks compared with Ins2^Akita heterozygotes

• compared with Rnf213^tm1.1Akoi homozygotes