Phenotypes Associated with This Genotype

Genotype
MGI:5510994

• Allelic Composition: Tg(ACTB-Eif4e)#Ppp/?
• Genetic Background: B6.Cg-Tg(ACTB-Eif4e)#Ppp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal inhibitory learning ( J:194400 )

♂ • although learning ability in the acquisition and memory phases of the water-based Y maze and modified Morris water maze tasks are intact, males are impaired in locating the new platform positions in the reversal phases

increased grooming behavior ( J:194400 )

♂ • mutants exhibit increased self grooming

hyperactivity ( J:194400 )

♂ • males exhibit mild hyperactivity, however no impairments in motor coordination, motor learning and sensorimotor gating

increased stereotypic behavior ( J:194400 )

♂ • males exhibit repetitive digging behavior in the marble-burying test

abnormal social investigation ( J:194400 )

♂ • males do not show a preference for a nonspecific stranger versus a new, inanimate object

♂ • males exhibit diminished reciprocal interactions with a freely moving stranger mouse

♂ • treatment with 4DGI-1, an inhibitor of Eif4e-Eif4g interactions, results in a decrease in repetitive behaviors, perseverative behaviors, and in social behavior deficits

nervous system

abnormal forebrain morphology ( J:194400 )

• about 12% increase in spine density and smaller spine volume in layer 2/3 medial prefrontal cortex pyramidal neurons

abnormal miniature excitatory postsynaptic currents ( J:194400 )

• mutants exhibit an increase in the frequency, but not amplitude, of miniature excitatory postsynaptic currents in layers 2/3 of acute medial prefrontal cortex slices

increased miniature inhibitory postsynaptic current amplitude ( J:194400 )

• mutants exhibit an increase in the amplitude, but not frequency, of miniature inhibitory postsynaptic currents in layers 2/3 of acute medial prefrontal cortex slices

abnormal long-term depression ( J:194400 )

• mutants exhibit enhanced long-term depression in the striatum

• mutants exhibit enhanced hippocampal metabotropic glutamate receptor dependent (mGluR)-long-term depression

• treatment with 4DGI-1, an inhibitor of Eif4e-Eif4g interactions, normalizes the enhanced striatal long term depression

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:194400