Phenotypes Associated with This Genotype

Genotype
MGI:5511052

• Allelic Composition: Postn^tm1Sjc/Postn^tm1Sjc
• Genetic Background: B6.Cg-Postn^tm1Sjc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal alveolar process morphology ( J:200192 )

• mutants fed a soft diet show alterations of the crestal alveolar bone and the deeper alveolar bone and cementum-enamel junction, particularly around the proximal root of the first molar

• mutants fed a soft diet exhibit a higher distance between the molar root and the enamel of the underlying incisor, indicating alveolar bone alteration

• treatment with zoledronate improves systemic and alveolar bone alterations in ovariectomized mice without producing jaw bone necrosis

abnormal periodontal ligament morphology ( J:200192 )

• 13 month old mutants fed a soft diet show some inflammatory infiltrates around the periodontal ligament but no signs of active inflammation in gingival, periradicular and jaw bone compartments indicating absence of overt periodontal disease

abnormal enamel morphology ( J:200192 )

• mutants fed a soft diet exhibit alteration of the enamel that affects the incisor from the apex to the incisor edge

abnormal mandible morphology ( J:200192 )

• large medullar spaces filled by fibrous tissue are seen in the mandibles of mutants fed a soft diet, whereas no fibrous tissue is seen in wild-type mice

• mutants fed a soft diet exhibit lower basal and alveolar bone volume fraction in the mandible

increased osteoclast cell number ( J:200192 )

• mutants fed a soft diet have a higher osteoclast number in the bone area between the molar root and the enamel of the underlying incisor

decreased bone mineral density ( J:200192 )

• mutants fed a soft diet exhibit alveolar and systemic osteopenia without overt periodontal disease

• intact and ovariectomized females exhibit lower femur bone mineral density

• treatment with zoledronate improves bone mineral density, femur trabecular bone volume on tissue volume and cortical bone volume in both wild-type and mutant ovariectomized females

decreased bone mineral density of femur ( J:200192 )

• intact and ovariectomized females exhibit lower femur bone mineral density

decreased compact bone volume ( J:200192 )

• intact and ovariectomized females exhibit lower cortical bone microarchitecture

decreased trabecular bone volume ( J:200192 )

• intact and ovariectomized females exhibit lower trabecular bone microarchitecture

abnormal bone ossification ( J:200192 )

• mutants fed a soft diet exhibit lower bone formation indices in the mandibles

• intact and ovariectomized females exhibit decreased bone formation indices in the femur and mandible

craniofacial

abnormal alveolar process morphology ( J:200192 )

• mutants fed a soft diet show alterations of the crestal alveolar bone and the deeper alveolar bone and cementum-enamel junction, particularly around the proximal root of the first molar

• mutants fed a soft diet exhibit a higher distance between the molar root and the enamel of the underlying incisor, indicating alveolar bone alteration

• treatment with zoledronate improves systemic and alveolar bone alterations in ovariectomized mice without producing jaw bone necrosis

abnormal periodontal ligament morphology ( J:200192 )

• 13 month old mutants fed a soft diet show some inflammatory infiltrates around the periodontal ligament but no signs of active inflammation in gingival, periradicular and jaw bone compartments indicating absence of overt periodontal disease

abnormal enamel morphology ( J:200192 )

• mutants fed a soft diet exhibit alteration of the enamel that affects the incisor from the apex to the incisor edge

abnormal mandible morphology ( J:200192 )

• large medullar spaces filled by fibrous tissue are seen in the mandibles of mutants fed a soft diet, whereas no fibrous tissue is seen in wild-type mice

• mutants fed a soft diet exhibit lower basal and alveolar bone volume fraction in the mandible

hematopoietic system

increased osteoclast cell number ( J:200192 )

• mutants fed a soft diet have a higher osteoclast number in the bone area between the molar root and the enamel of the underlying incisor

immune system

increased osteoclast cell number ( J:200192 )

• mutants fed a soft diet have a higher osteoclast number in the bone area between the molar root and the enamel of the underlying incisor

growth/size/body

abnormal alveolar process morphology ( J:200192 )

• mutants fed a soft diet show alterations of the crestal alveolar bone and the deeper alveolar bone and cementum-enamel junction, particularly around the proximal root of the first molar

• mutants fed a soft diet exhibit a higher distance between the molar root and the enamel of the underlying incisor, indicating alveolar bone alteration

• treatment with zoledronate improves systemic and alveolar bone alterations in ovariectomized mice without producing jaw bone necrosis

abnormal periodontal ligament morphology ( J:200192 )

• 13 month old mutants fed a soft diet show some inflammatory infiltrates around the periodontal ligament but no signs of active inflammation in gingival, periradicular and jaw bone compartments indicating absence of overt periodontal disease

abnormal enamel morphology ( J:200192 )

• mutants fed a soft diet exhibit alteration of the enamel that affects the incisor from the apex to the incisor edge

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
bone structure disease		DOID:0080010		J:200192