Phenotypes Associated with This Genotype

Genotype
MGI:5514279

tg2

• Allelic Composition: Tg(CTSG-RARA/ZBTB16)#Ppp/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased apoptosis ( J:65878 )

• overall rate of bone marrow cell apoptosis and growth factor deprivation-induced programmed cell death is reduced

hematopoietic system

enlarged spleen ( J:65878 )

• approximately 20% of mutants develop splenomegaly after the first year of life

abnormal myelopoiesis ( J:65878 )

• perturbed myelopoiesis, with slow and progressive accumulation of myeloid cells in the bone marrow and spleen; these cells retain the ability to terminally differentiate into mature granulocytes

myeloid hyperplasia ( J:65878 )

• progressive hyperplasia of the myeloid/granulocytic compartment in the bone marrow

thrombocytopenia ( J:65878 )

• low platelet counts in the peripheral blood

immune system

enlarged spleen ( J:65878 )

• approximately 20% of mutants develop splenomegaly after the first year of life

abnormal myelopoiesis ( J:65878 )

• perturbed myelopoiesis, with slow and progressive accumulation of myeloid cells in the bone marrow and spleen; these cells retain the ability to terminally differentiate into mature granulocytes

myeloid hyperplasia ( J:65878 )

• progressive hyperplasia of the myeloid/granulocytic compartment in the bone marrow

neoplasm

neoplasm ( J:65878 )

N • mutants do not develop leukemia

growth/size/body

enlarged spleen ( J:65878 )

• approximately 20% of mutants develop splenomegaly after the first year of life