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Phenotypes Associated with This Genotype
Genotype
MGI:5514344
Allelic
Composition		 Tg(CTSG-ZBTB16/RARA)#Ppp/0
Zbtb16tm1Ppp/Zbtb16tm1Ppp
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CTSG-ZBTB16/RARA)#Ppp mutation (0 available)
Zbtb16tm1Ppp mutation (0 available); any Zbtb16 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased acute promyelocytic leukemia incidence ( J:65878 )
• develop leukemia after 6 months of age characterized by an accumulation of blast/promyelocytic cells in the bone marrow and spleen in the absence of leukocytosis resembling acute promyelocytic leukemia
• leukemia is also characterized by infiltrating cells that are c-Kit, Gr-1, Mac-1 positive and display promyelocytic features

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
acute promyelocytic leukemia DOID:0060318 OMIM:612376
 J:65878

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory