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Phenotypes Associated with This Genotype
Genotype
MGI:5515317
Allelic
Composition
Sh2d1atm1Lyin/Y
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Lyin mutation (0 available); any Sh2d1a mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• CD8+ T cell numbers are significantly increased relative to controls after gammaherpesvirus-68 infections
• deficiency present at all ages
• levels were consistently lower than normal

immune system
• CD8+ T cell numbers are significantly increased relative to controls after gammaherpesvirus-68 infections
• deficiency present at all ages
• levels were consistently lower than normal
• although response to gammaherpesvirus-68 function was similar to wild-type in that there was no observed mortality and morbidity and acute viral infections were cleared, severe and persistent inflammatory responses were found in lungs and liver that were much slower to resolve

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
X-linked lymphoproliferative syndrome 1 DOID:0060705 OMIM:308240
J:97346


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory