Phenotypes for Prdm1 Tg(Itgax-cre)1-1Reiz MGI:5515634 MGI Mouse

abnormal T follicular helper cell differentiation ( J:178876 )

• generation of follicular T helper cells cells is enhanced when mutant dendritic cells are cultured with naive T cells from control mice in the presence of differentiation factors, indicating increased differentiation of these cells

increased germinal center B cell number ( J:178876 )

• more spontaneous germinal center B cells

increased T follicular helper cell number ( J:178876 )

• increase in the percentage and number of follicular T helper cells

increased spleen germinal center number ( J:178876 )

• more germinal centers in the spleen

increased splenocyte number ( J:178876 )

• total number of splenocytes are increased in females but not males

abnormal immune system physiology ( J:178876 )

• enhanced immune response after NP-CGG immunization with an increased high-affinity anti-NP IgG response, an increase in the number of germinal center B cells, and an increase in the number of total germinal cells and antigen-specific germinal cells

abnormal germinal center B cell physiology ( J:178876 )

• enhanced germinal center response in young mice

increased immunoglobulin level ( J:178876 )

• total serum immunoglobulin levels are increased in females but not males

increased IgG level ( J:178876 )

• kidney deposition of IgG in 10 month old females

abnormal CD4-positive, alpha-beta T cell physiology ( J:178876 )

• increase in expression of ICOS in CD4+ T cells, indicating that mice have more activated CD4+ T cells than controls

increased interleukin-6 secretion ( J:178876 )

• increase in production of IL-6 by splenic dendritic cells and by bone marrow derived dendritic cells after LPS stimulation in females but not males

increased autoantibody level ( J:178876 )

• females, but not males, develop autoantibodies as early as 4-5 months of age, including anti-nuclear antibodies, anti-double stranded dNA, and anti-ENA5, which are all IgG

increased anti-nuclear antigen antibody level ( J:178876 )

increased anti-double stranded DNA antibody level ( J:178876 )

• IgG2b is the major isotype of anti-dsDNA antibodies

kidney inflammation ( J:178876 )

• inflammatory infiltrates in 10 month old females

increased urine protein level ( J:178876 )

• proteinuria in 10 month old females

kidney inflammation ( J:178876 )

• inflammatory infiltrates in 10 month old females

abnormal kidney morphology ( J:178876 )

• kidney deposition of IgG in 10 month old females

abnormal mesangial cell morphology ( J:178876 )

• mesangial cell proliferation in 10 month old females

abnormal T follicular helper cell differentiation ( J:178876 )

• generation of follicular T helper cells cells is enhanced when mutant dendritic cells are cultured with naive T cells from control mice in the presence of differentiation factors, indicating increased differentiation of these cells

increased germinal center B cell number ( J:178876 )

• more spontaneous germinal center B cells

increased T follicular helper cell number ( J:178876 )

• increase in the percentage and number of follicular T helper cells

increased spleen germinal center number ( J:178876 )

• more germinal centers in the spleen

increased splenocyte number ( J:178876 )

• total number of splenocytes are increased in females but not males

abnormal germinal center B cell physiology ( J:178876 )

• enhanced germinal center response in young mice

increased immunoglobulin level ( J:178876 )

• total serum immunoglobulin levels are increased in females but not males

increased IgG level ( J:178876 )

• kidney deposition of IgG in 10 month old females

abnormal CD4-positive, alpha-beta T cell physiology ( J:178876 )

• increase in expression of ICOS in CD4+ T cells, indicating that mice have more activated CD4+ T cells than controls

increased urine protein level ( J:178876 )

• proteinuria in 10 month old females

abnormal mesangial cell morphology ( J:178876 )

• mesangial cell proliferation in 10 month old females

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:178876

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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