Phenotypes for Prdm1 Tg(Itgax-cre)1-1Reiz MGI:5515634 MGI Mouse

abnormal T follicular helper cell differentiation ( J:178876 )

• generation of follicular T helper cells cells is enhanced when mutant dendritic cells are cultured with naive T cells from control mice in the presence of differentiation factors, indicating increased differentiation of these cells

increased germinal center B cell number ( J:178876 )

• more spontaneous germinal center B cells

increased T follicular helper cell number ( J:178876 )

• increase in the percentage and number of follicular T helper cells

increased spleen germinal center number ( J:178876 )

• more germinal centers in the spleen

increased splenocyte number ( J:178876 )

• total number of splenocytes are increased in females but not males

abnormal immune system physiology ( J:178876 )

• enhanced immune response after NP-CGG immunization with an increased high-affinity anti-NP IgG response, an increase in the number of germinal center B cells, and an increase in the number of total germinal cells and antigen-specific germinal cells

abnormal germinal center B cell physiology ( J:178876 )

• enhanced germinal center response in young mice

increased immunoglobulin level ( J:178876 )

• total serum immunoglobulin levels are increased in females but not males

increased IgG level ( J:178876 )

• kidney deposition of IgG in 10 month old females

abnormal CD4-positive, alpha-beta T cell physiology ( J:178876 )

• increase in expression of ICOS in CD4+ T cells, indicating that mice have more activated CD4+ T cells than controls

increased interleukin-6 secretion ( J:178876 )

• increase in production of IL-6 by splenic dendritic cells and by bone marrow derived dendritic cells after LPS stimulation in females but not males

increased autoantibody level ( J:178876 )

• females, but not males, develop autoantibodies as early as 4-5 months of age, including anti-nuclear antibodies, anti-double stranded dNA, and anti-ENA5, which are all IgG

increased anti-nuclear antigen antibody level ( J:178876 )

increased anti-double stranded DNA antibody level ( J:178876 )

• IgG2b is the major isotype of anti-dsDNA antibodies

kidney inflammation ( J:178876 )

• inflammatory infiltrates in 10 month old females

increased urine protein level ( J:178876 )

• proteinuria in 10 month old females

kidney inflammation ( J:178876 )

• inflammatory infiltrates in 10 month old females

abnormal kidney morphology ( J:178876 )

• kidney deposition of IgG in 10 month old females

abnormal mesangial cell morphology ( J:178876 )

• mesangial cell proliferation in 10 month old females

abnormal T follicular helper cell differentiation ( J:178876 )

• generation of follicular T helper cells cells is enhanced when mutant dendritic cells are cultured with naive T cells from control mice in the presence of differentiation factors, indicating increased differentiation of these cells

increased germinal center B cell number ( J:178876 )

• more spontaneous germinal center B cells

increased T follicular helper cell number ( J:178876 )

• increase in the percentage and number of follicular T helper cells

increased spleen germinal center number ( J:178876 )

• more germinal centers in the spleen

increased splenocyte number ( J:178876 )

• total number of splenocytes are increased in females but not males

abnormal germinal center B cell physiology ( J:178876 )

• enhanced germinal center response in young mice

increased immunoglobulin level ( J:178876 )

• total serum immunoglobulin levels are increased in females but not males

increased IgG level ( J:178876 )

• kidney deposition of IgG in 10 month old females

abnormal CD4-positive, alpha-beta T cell physiology ( J:178876 )

• increase in expression of ICOS in CD4+ T cells, indicating that mice have more activated CD4+ T cells than controls

increased urine protein level ( J:178876 )

• proteinuria in 10 month old females

abnormal mesangial cell morphology ( J:178876 )

• mesangial cell proliferation in 10 month old females

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:178876

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24