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Phenotypes Associated with This Genotype
Genotype
MGI:5515639
cn6
Allelic
Composition		 Il6tm1Kopf/Il6+
Prdm1tm1Clme/Prdm1tm1Clme
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6tm1Kopf mutation (9 available); any Il6 mutation (38 available)
Prdm1tm1Clme mutation (1 available); any Prdm1 mutation (66 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:178876 )
N
• mice do not develop autoantibodies, they mount an antibody response indistinguishable from control mice to NP-CGG, dendritic cells express the same level of IL-6 as dendritic cells from control mice after LPS stimulation, and show normal levels of follicular T helper cells and germinal cells in the spleen

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory