Phenotypes Associated with This Genotype

Genotype
MGI:5515773

cx2

• Allelic Composition: Car5a^tm1Sly/Car5a^tm1Sly; Car5b^tm1Sly/Car5b^tm1Sly
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:196135 )

♀ • females are significantly smaller than controls

mortality/aging

premature death ( J:196135 )

♀ • die prematurely beginning shortly after weaning

preweaning lethality, incomplete penetrance ( J:196135 )

♀ • 11 females compared to 17 for controls

homeostasis/metabolism

increased circulating ammonia level ( J:196135 )

♀ • significantly elevated, higher than in Car5a^tm1Sly homozygotes

decreased circulating glucose level ( J:196135 )

♀ • fasting blood sugar is significantly lower than in controls

♀ • blood sugar is similar to controls when fed

cellular

oxidative stress ( J:181790 )

♀ • reduced oxidative stress in the brain

♀ • elevated levels of glutathione

♀ • reduced SOD, HNE, and 3-NT