Phenotypes Associated with This Genotype

Genotype
MGI:5515788

cx1

• Allelic Composition: Dnmt3b^MommeD14/Dnmt3b^MommeD14; Tg(HBA1-GFP)1Ew/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal epigenetic regulation of gene expression ( J:198944 )

• surviving homozygous mice displayed a higher percentage of GFP-expressing cells than did the heterozygotes

• significantly reduced methylation of transgene DNA in homozygous individuals (28 % of CpGs methylated) compared with wild type littermates (62 % of CpGs methylated), consistent with the change in transcriptional activity

mortality/aging

preweaning lethality, incomplete penetrance ( J:198944 )

• heterozygous intercrosses only resulted in 10% of homozygous offspring instead of the expected 25%