Phenotypes Associated with This Genotype

Genotype
MGI:5515792

cx2

• Allelic Composition: Dnmt3b^MommeD14/Dnmt3b^tm1Enl; Tg(HBA1-GFP)1Ew/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal epigenetic regulation of gene expression ( J:198944 )

• compound heterozygous mice display a higher percentage of GFP-expressing cells than heterozygotes

• significantly reduced methylation of transgene DNA in homozygous individuals (28 % of CpGs methylated) compared with wild type littermates (62 % of CpGs methylated), consistent with the change in transcriptional activity

growth/size/body

abnormal head morphology ( J:198944 )

• hypotelorism and other cranial defects are seen, similar to phenotypes of other alleles of this gene

decreased body height ( J:198944 )

• small in stature