Phenotypes for Cdkn2a Sox10 Tg(Tyr-NRAS*Q61K)1Bee MGI:5515809 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Sox10^tm1Weg/Sox10⁺ Tg(Tyr-NRAS*Q61K)1Bee/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (6 available); any Cdkn2a mutation (66 available)
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:193443 )

N	• loss of the hyperpigmentation that is seen in Cdkn2a^tm1Rdp/ Cdkn2a^tm1Rdp Tg(Tyr-NRAS*Q61K)1Bee/0 mice resulting in an almost normal pigmentation pattern

neoplasm

neoplasm ( J:193443 )

N	• no signs of primary melanoma formation are seen at 6 months of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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