endocrine/exocrine glands
• mammary glands of virgin females show a decrease in the expansion of luminal progenitors seen in single Cdkn2c homozygotes to normal levels but show an increase in the expansion of basal/myoepithelial cells
|
• 38% of mutants develop breast cancer before 1 year of age and 87% by 22 months of age
• mammary tumors show high degree of heterogeneity, increased population of CK5+ cells, loss of wild-type allele of Brca1 in CK5+ tumor cells, ERalpha negativity and invasiveness and metastasis
• mammary tumors are transformed from a luminal subtype that is seen in single Cdkn2c homozygotes into a basal-like subtype
|
• poorly differentiated carcinoma with squamous metaplasia
|
integument
• mammary glands of virgin females show a decrease in the expansion of luminal progenitors seen in single Cdkn2c homozygotes to normal levels but show an increase in the expansion of basal/myoepithelial cells
|
• 38% of mutants develop breast cancer before 1 year of age and 87% by 22 months of age
• mammary tumors show high degree of heterogeneity, increased population of CK5+ cells, loss of wild-type allele of Brca1 in CK5+ tumor cells, ERalpha negativity and invasiveness and metastasis
• mammary tumors are transformed from a luminal subtype that is seen in single Cdkn2c homozygotes into a basal-like subtype
|
• poorly differentiated carcinoma with squamous metaplasia
|
neoplasm
• 38% of mutants develop breast cancer before 1 year of age and 87% by 22 months of age
• mammary tumors show high degree of heterogeneity, increased population of CK5+ cells, loss of wild-type allele of Brca1 in CK5+ tumor cells, ERalpha negativity and invasiveness and metastasis
• mammary tumors are transformed from a luminal subtype that is seen in single Cdkn2c homozygotes into a basal-like subtype
|
• poorly differentiated carcinoma with squamous metaplasia
|
• 4 of 13 (31%) mammary tumors metastasize to the lung and blood vessels after 1 year of age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
breast cancer | DOID:1612 |
OMIM:114480 |
J:198018 |