Phenotypes Associated with This Genotype

Genotype
MGI:5517669

• Allelic Composition: Snca^tm1.1Koks/Snca⁺
• Genetic Background: either: B6.129P2-Snca^tm1.1Koks or (involves: 129P2/OlaHsd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:201391 )

• slipping on a narrow beam in mice older than 13 months

• however, mice exhibit no difference in slips on a wide beam and normal performance on a rotarod

abnormal locomotor activation ( J:201391 )

• reserpine-treated mice fail to exhibit increased amphetamine-induced activity unlike wild-type mice

long stride length ( J:201391 )

• at 16 months

catalepsy ( J:201391 )

• reserpine-treated mice exhibit increased amphetamine-induced catalepsy unlike wild-type mice

homeostasis/metabolism

decreased dopamine level ( J:201391 )

• in the striatum and mesolimbic area

decreased physiological sensitivity to xenobiotic ( J:201391 )

• reserpine-treated mice fail to exhibit increased amphetamine-induced activity and exhibit increased catalepsy unlike wild-type mice

• however, reserpine-treated mice exhibit normal hypothermia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 1		DOID:0060367	OMIM:168601	J:201391