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Phenotypes Associated with This Genotype
Genotype
MGI:5518637
cn8
Allelic
Composition		 Gli3tm1Alj/Gli3tm1Alj
Nkx3-2tm1(cre)Wez/Nkx3-2+
Smotm2Amc/Smotm2Amc
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3tm1Alj mutation (1 available); any Gli3 mutation (81 available)
Nkx3-2tm1(cre)Wez mutation (0 available); any Nkx3-2 mutation (21 available)
Smotm2Amc mutation (1 available); any Smo mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Gli2 expression, but not Gli3 de-repression, rescues intestinal phenotypes in Smotm2Amc/Smotm2Amc Nkx3-2tm1(cre)Wez/Nkx3-2+ embryos

digestive/alimentary system
abnormal digestive system morphology ( J:199664 )
• mice exhibit the same defects as in Nkx3-2tm1(cre)Wez/Nkx3-2+ Smom2Amc/Smom2Amc mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory