Phenotypes Associated with This Genotype

Genotype
MGI:5519095

• Allelic Composition: Rb1^tm3Tyj/Rb1⁺; Trp53^tm1Brn/Trp53^tm1Brn; Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CD-1 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:136693 )

• die from around 125 to 260 days of age

neoplasm

increased metastatic potential ( J:136693 )

• tumors show metastasis, most frequently to the lung and then the liver

increased osteosarcoma incidence ( J:136693 )

• develop osteosarcomas at around 4 months of age with 100% penetrance and average latency of 158 days of age

skeleton

increased osteosarcoma incidence ( J:136693 )

• develop osteosarcomas at around 4 months of age with 100% penetrance and average latency of 158 days of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteosarcoma		DOID:3347	OMIM:259500	J:136693