Phenotypes Associated with This Genotype

Genotype
MGI:5519120

• Allelic Composition: Del(16Dgcr2-Hira)3Aam/+
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial working memory ( J:158957 )

• mutants require more training in the T-maze task than controls to reach criterion, indicating a learning impairment

nervous system

abnormal nervous system physiology ( J:158957 )

• hippocampal-prefrontal synchrony is reduced during working memory performance on the discrete-trial T-maze task

• phase-locking of prefrontal neurons to hippocampal theta oscillations and coherence of prefrontal and hippocampal local field potentials are reduced

• coherence is lower in mutants before training when tested on center-arm runs during habituation, indicating that hippocampal-prefrontal circuit synchrony is impaired at baseline

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:158957