Phenotypes Associated with This Genotype

Genotype
MGI:5521202

• Allelic Composition: Tg(Thy1-Tcf4)1Mjro/0
• Genetic Background: involves: C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal associative learning ( J:197081 )

♂ • freezing performance in the novel context before conditioning and during the presentation of first auditory cue is normal, however mutants show more freezings during the presentation of tone 2 when compared with tone 1, indicating impaired trace fear conditioning

♂ • in the remote trace memory test, during presentation of tone 1 and tone 2, mutants show less freezing and in the first interval of post-tone 1, mice also show less freezing than controls, indicating reduced remote trace fear memory formation

♂ • in recent and remote trace memory tests, mutants show fewer freezings in a time window following auditory cue (post-tone), indicating a reduced ability to anticipate the aversive foot shock

impaired contextual conditioning behavior ( J:197081 , J:202664 )

♂ • mice show fewer freezings than controls when trained in the trace paradigm (exposed on consecutive day to the same context as during conditioning), indicating impaired recent contextual fear memory (J:197081)

♂ • prior to the cued trace memory test, mice show normal freezing behavior in a novel context, although mutants show a tendency toward lower freezing rate (J:197081)

♂ • however, mutants show normal remote contextual memory and normal non-associate freezing and initial acquisition (J:197081)

♂ • upon two foot-shocks, mice show reduced freezing in the contextual and cue memory tests, indicating impaired fear memory (J:202664)

♂ • however, no significant differences are seen with five tone-food sock pairings (J:202664)

♂ • contextual fear memory formation is slightly more altered during the dark phase at Zeitgeber times 17-19 compared with at Zeitgeber times 4-6 (J:202664)

impaired cued conditioning behavior ( J:197081 , J:202664 )

♂ • for the cued trace memory test in which mice were presented with 3 tones separated temporally by periods corresponding to trace intervals, mutants show less freezings during the presentation of tone 1, 2, and 3, indicating impaired trace fear memory (J:197081)

♂ • upon two foot-shocks, mice show reduced freezing in the contextual and cue memory tests, indicating impaired fear memory (J:202664)

♂ • cued fear memory formation is slightly more altered during the dark phase at Zeitgeber times 17-19 compared with at Zeitgeber times 4-6 (J:202664)

impaired spatial learning ( J:202664 )

♂ • on the first and second day of the reversal training on the water maze task, mice show greater escape latencies, indicating a slight impairment in cognitive flexibility

♂ • however, mice exhibit proper visual perception and normal initial and reversal learning tasks

increased thigmotaxis ( J:202664 )

♂ • the relative time spent in the center versus the periphery is slightly but significantly less then in controls during the dark phase under dim red light at Zeitgeber times 17-19, indicating altered level of anxiety that is not observed during the light phase at Zeitgeber times 4-6

♂ • mice, however, show similar activity, exploratory, motor and motivational behavior, and pain sensitivity as controls during light phase (Zeitgeber times 4-6)

nervous system

reduced sensorimotor gating ( J:202664 )

♂ • prepulse inhibition is impaired indicating impaired sensorimotor gating

abnormal prepulse inhibition ( J:202664 )

♂ • prepulse inhibition is impaired, most prominently at the 75 dB prepulse, indicating impaired sensorimotor gating

♂ • however, startle response is normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:197081