Phenotypes Associated with This Genotype

Genotype
MGI:5521544

• Allelic Composition: Trp53^tm1Brn/Trp53^tm1Brn; Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

increased osteosarcoma incidence ( J:199542 )

• mutants develop osteosarcoma with a mean latency of 226.5 days

• 25% of tumors are found on the mandible/head, 50% of tumors are found on the lower long bones, and 25% of tumors are in other axial locations

• osteosarcoma is characterized by predominant areas of fibroblastic (undifferentiated) morphology accompanied by intermittent areas of mineralized osteoid resembling human fibroblastic/undifferentiated osteosarcoma

mortality/aging

premature death ( J:199542 )

• mutants have a median survival of 226.5 days of age

decreased tumor-free survival time ( J:319454 )

neoplasm

increased metastatic potential ( J:199542 )

• 50% of mice show metastatic dissemination, commonly to the lung and liver

increased osteosarcoma incidence ( J:199542 )

• mutants develop osteosarcoma with a mean latency of 226.5 days

• 25% of tumors are found on the mandible/head, 50% of tumors are found on the lower long bones, and 25% of tumors are in other axial locations

• osteosarcoma is characterized by predominant areas of fibroblastic (undifferentiated) morphology accompanied by intermittent areas of mineralized osteoid resembling human fibroblastic/undifferentiated osteosarcoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteosarcoma		DOID:3347	OMIM:259500	J:199542