Phenotypes Associated with This Genotype

Genotype
MGI:5521546

• Allelic Composition: Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0; Tg(tetO-RNAi:Trp53)ASlowe/0
• Genetic Background: involves: C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:199542 )

• median survival is 485 days of age

neoplasm

increased metastatic potential ( J:199542 )

• 83.3% of mice show metastatic dissemination, commonly to the lung and liver

increased osteosarcoma incidence ( J:199542 )

• mutants develop osteosarcoma with a mean latency of 485 days

• 66.7% of tumors are in the long bones, 16.7% of tumors are found in the mandible/head, and 16.7% of tumors are in other axial locations

• osteosarcoma is characterized by a uniform heavily mineralized osteoblastic (well differentiated) appearance in both primary and metastatic sites and osteosarcomas fail to become adipogenic under inductive conditions, indicating a cell population that is osteoblast restricted

• tumors resemble human osteoblastic osteosarcoma

skeleton

increased osteosarcoma incidence ( J:199542 )

• mutants develop osteosarcoma with a mean latency of 485 days

• 66.7% of tumors are in the long bones, 16.7% of tumors are found in the mandible/head, and 16.7% of tumors are in other axial locations

• osteosarcoma is characterized by a uniform heavily mineralized osteoblastic (well differentiated) appearance in both primary and metastatic sites and osteosarcomas fail to become adipogenic under inductive conditions, indicating a cell population that is osteoblast restricted

• tumors resemble human osteoblastic osteosarcoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteosarcoma		DOID:3347	OMIM:259500	J:199542