Phenotypes Associated with This Genotype

Genotype
MGI:5523889

• Allelic Composition: Scn1a^tm2.1Kzy/Scn1a^tm2.1Kzy; Tg(Pvalb-cre)1Tama/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:202863 )

• all animals die before P30

behavior/neurological

ataxia ( J:202863 )

• develops around P14

convulsive seizures ( J:202863 )

• mice are physically normal for first week postnatal, but around P10 develop spontaneous generalized convulsive seizures

nervous system

convulsive seizures ( J:202863 )

• mice are physically normal for first week postnatal, but around P10 develop spontaneous generalized convulsive seizures

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Dravet syndrome		DOID:0080422	OMIM:607208	J:202863