Phenotypes Associated with This Genotype

Genotype
MGI:5523927

• Allelic Composition: Tg(SFTPC-EZR/ROS1)AShiba/0
• Genetic Background: C57BL/6-Tg(SFTPC-EZR/ROS1)AShiba

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:199415 )

• reduction in survival due to adenocarcinoma

neoplasm

increased lung adenocarcinoma incidence ( J:199415 )

• mutants develop lung adenocarcinoma, with mice showing lesions over 1 mm in diameter already at 4 weeks of age and tumors occupy over 40% of lung surface at this time

• lung tumors are adenocarcinomas with papillary/lepidic growth pattern

• distant metastasis is not observed

respiratory system

increased lung adenocarcinoma incidence ( J:199415 )

• mutants develop lung adenocarcinoma, with mice showing lesions over 1 mm in diameter already at 4 weeks of age and tumors occupy over 40% of lung surface at this time

• lung tumors are adenocarcinomas with papillary/lepidic growth pattern

• distant metastasis is not observed

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:199415