Phenotypes Associated with This Genotype

Genotype
MGI:5524084

• Allelic Composition: Tg(MMTV-Myc)WT13Jrn/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:153233 , J:193362 )

• mutants develop mammary tumors (J:153233)

• nearly 40% of mammary tumors are microacinar, with the remainder of tumors showing various other morphologies including, papillary, squamous, epithelial-mesenchymal-transition (EMT) type, solid, adenocarcinoma and tumors with mixed population of various types of tumors (J:153233)

• the squamous/EMT subgroup of tumors shares attributes of human triple-negative breast cancer and is associated with an increase in risk of metastasis (J:153233)

• Kras activating mutations are seen in 22.4% of tumors (J:193362)

• mice with tumors containing a Kras mutation show a reduction in latency compared to mice with tumors without a mutation (J:193362)

• microacinar type tumors show similar expression profiles to human luminal B tumors (J:193362)

• epithelial-mesenchymal-transition (EMT) subtype tumors have an elevation in the frequency of activating Kras mutations compared to the other types of tumors seen in mutants and show similar expression profiles to human claudin-low tumors (J:193362)

increased mammary adenocarcinoma incidence ( J:153233 )

increased metastatic potential ( J:153233 )

• pulmonary metastasis is sometimes observed and is associated with the squamous/EMT subgroup of tumors

endocrine/exocrine glands

abnormal mammary gland development ( J:193362 )

• mammary glands show increased side bud formation at 8 weeks of age

increased mammary gland tumor incidence ( J:153233 , J:193362 )

• mutants develop mammary tumors (J:153233)

• nearly 40% of mammary tumors are microacinar, with the remainder of tumors showing various other morphologies including, papillary, squamous, epithelial-mesenchymal-transition (EMT) type, solid, adenocarcinoma and tumors with mixed population of various types of tumors (J:153233)

• the squamous/EMT subgroup of tumors shares attributes of human triple-negative breast cancer and is associated with an increase in risk of metastasis (J:153233)

• Kras activating mutations are seen in 22.4% of tumors (J:193362)

• mice with tumors containing a Kras mutation show a reduction in latency compared to mice with tumors without a mutation (J:193362)

• microacinar type tumors show similar expression profiles to human luminal B tumors (J:193362)

• epithelial-mesenchymal-transition (EMT) subtype tumors have an elevation in the frequency of activating Kras mutations compared to the other types of tumors seen in mutants and show similar expression profiles to human claudin-low tumors (J:193362)

increased mammary adenocarcinoma incidence ( J:153233 )

integument

abnormal mammary gland development ( J:193362 )

• mammary glands show increased side bud formation at 8 weeks of age

increased mammary gland tumor incidence ( J:153233 , J:193362 )

• mutants develop mammary tumors (J:153233)

• nearly 40% of mammary tumors are microacinar, with the remainder of tumors showing various other morphologies including, papillary, squamous, epithelial-mesenchymal-transition (EMT) type, solid, adenocarcinoma and tumors with mixed population of various types of tumors (J:153233)

• the squamous/EMT subgroup of tumors shares attributes of human triple-negative breast cancer and is associated with an increase in risk of metastasis (J:153233)

• Kras activating mutations are seen in 22.4% of tumors (J:193362)

• mice with tumors containing a Kras mutation show a reduction in latency compared to mice with tumors without a mutation (J:193362)

• microacinar type tumors show similar expression profiles to human luminal B tumors (J:193362)

• epithelial-mesenchymal-transition (EMT) subtype tumors have an elevation in the frequency of activating Kras mutations compared to the other types of tumors seen in mutants and show similar expression profiles to human claudin-low tumors (J:193362)

increased mammary adenocarcinoma incidence ( J:153233 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:193362