Phenotypes Associated with This Genotype

Genotype
MGI:5524086

• Allelic Composition: Tg(MMTV-Myc*T58A)TA14Jrn/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:153233 , J:193362 )

• mutants develop mammary tumors (J:153233)

• less than 10% of tumors are microacinar (J:153233)

• 40% of tumors exhibit a papillary histology, characterized by fibrovascular stalks lined by columnar cells that extend into gland-like spaces (J:153233)

• the remainder of tumors show various other morphologies including, squamous, epithelial-mesenchymal-transition type (EMT), solid, adenocarcinoma and tumors with mixed population of various types of tumors (J:153233)

• Kras activating mutations are seen in 14.6% of tumors (J:193362)

• mice with tumors containing a Kras mutation show a similar latency compared to mice with tumors without a mutation (J:193362)

• EMT subtype tumors have an elevation in the frequency of activating Kras mutations compared to the other types of tumors seen in mutants and show similar expression profiles to human claudin-low tumors (J:193362)

increased mammary adenocarcinoma incidence ( J:153233 )

endocrine/exocrine glands

abnormal mammary gland development ( J:193362 )

• mammary glands show increased side bud formation at 8 weeks of age

increased mammary gland tumor incidence ( J:153233 , J:193362 )

• mutants develop mammary tumors (J:153233)

• less than 10% of tumors are microacinar (J:153233)

• 40% of tumors exhibit a papillary histology, characterized by fibrovascular stalks lined by columnar cells that extend into gland-like spaces (J:153233)

• the remainder of tumors show various other morphologies including, squamous, epithelial-mesenchymal-transition type (EMT), solid, adenocarcinoma and tumors with mixed population of various types of tumors (J:153233)

• EMT subtype tumors have an elevation in the frequency of activating Kras mutations compared to the other types of tumors seen in mutants and show similar expression profiles to human claudin-low tumors (J:193362)

• Kras activating mutations are seen in 14.6% of tumors (J:193362)

• mice with tumors containing a Kras mutation show a similar latency compared to mice with tumors without a mutation (J:193362)

increased mammary adenocarcinoma incidence ( J:153233 )

integument

abnormal mammary gland development ( J:193362 )

• mammary glands show increased side bud formation at 8 weeks of age

increased mammary gland tumor incidence ( J:153233 , J:193362 )

• mutants develop mammary tumors (J:153233)

• less than 10% of tumors are microacinar (J:153233)

• 40% of tumors exhibit a papillary histology, characterized by fibrovascular stalks lined by columnar cells that extend into gland-like spaces (J:153233)

• the remainder of tumors show various other morphologies including, squamous, epithelial-mesenchymal-transition type (EMT), solid, adenocarcinoma and tumors with mixed population of various types of tumors (J:153233)

• Kras activating mutations are seen in 14.6% of tumors (J:193362)

• mice with tumors containing a Kras mutation show a similar latency compared to mice with tumors without a mutation (J:193362)

• EMT subtype tumors have an elevation in the frequency of activating Kras mutations compared to the other types of tumors seen in mutants and show similar expression profiles to human claudin-low tumors (J:193362)

increased mammary adenocarcinoma incidence ( J:153233 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:193362