Phenotypes Associated with This Genotype

Genotype
MGI:5524087

• Allelic Composition: Tg(MMTV-Myc*T58A)TA41Jrn/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:153233 , J:193362 )

• mutants develop mammary tumors (J:153233)

• less than 10% of tumors are microacinar (J:153233)

• 40% of tumors exhibit a papillary histology, characterized by fibrovascular stalks lined by columnar cells that extend into gland-like spaces (J:153233)

• the remainder of tumors show various other morphologies including, squamous, epithelial-mesenchymal-transition (EMT) type, solid, adenocarcinoma and tumors with mixed population of various types of tumors (J:153233)

• Kras activating mutations are seen in 16.1% of tumors (J:193362)

• mice with tumors containing a Kras mutation show a similar latency compared to mice with tumors without a mutation (J:193362)

• EMT subtype tumors have an elevation in the frequency of activating Kras mutations compared to the other types of tumors seen in mutants (J:193362)

• EMT subtype tumors show similar expression profiles to human claudin-low tumors (J:193362)

increased mammary adenocarcinoma incidence ( J:153233 )

integument

increased mammary gland tumor incidence ( J:153233 , J:193362 )

• mutants develop mammary tumors (J:153233)

• less than 10% of tumors are microacinar (J:153233)

• 40% of tumors exhibit a papillary histology, characterized by fibrovascular stalks lined by columnar cells that extend into gland-like spaces (J:153233)

• the remainder of tumors show various other morphologies including, squamous, epithelial-mesenchymal-transition (EMT) type, solid, adenocarcinoma and tumors with mixed population of various types of tumors (J:153233)

• Kras activating mutations are seen in 16.1% of tumors (J:193362)

• mice with tumors containing a Kras mutation show a similar latency compared to mice with tumors without a mutation (J:193362)

• EMT subtype tumors have an elevation in the frequency of activating Kras mutations compared to the other types of tumors seen in mutants (J:193362)

• EMT subtype tumors show similar expression profiles to human claudin-low tumors (J:193362)

increased mammary adenocarcinoma incidence ( J:153233 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:153233 , J:193362 )

• mutants develop mammary tumors (J:153233)

• less than 10% of tumors are microacinar (J:153233)

• 40% of tumors exhibit a papillary histology, characterized by fibrovascular stalks lined by columnar cells that extend into gland-like spaces (J:153233)

• the remainder of tumors show various other morphologies including, squamous, epithelial-mesenchymal-transition (EMT) type, solid, adenocarcinoma and tumors with mixed population of various types of tumors (J:153233)

• Kras activating mutations are seen in 16.1% of tumors (J:193362)

• mice with tumors containing a Kras mutation show a similar latency compared to mice with tumors without a mutation (J:193362)

• EMT subtype tumors have an elevation in the frequency of activating Kras mutations compared to the other types of tumors seen in mutants (J:193362)

• EMT subtype tumors show similar expression profiles to human claudin-low tumors (J:193362)

increased mammary adenocarcinoma incidence ( J:153233 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:193362