Phenotypes Associated with This Genotype

Genotype
MGI:5526032

• Allelic Composition: Tg(Snca-SNCA)#Galt/?
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

taste/olfaction

impaired olfaction ( J:199939 )

• in the odor detection test, mutants require a higher concentration of odor to detect it, indicating impaired odor detection

• the odor detection impairment is age-dependent, with normal detection at 3 months but impaired at 11 and 18 months of age

• treatment of 10-11 month old mutants with rasagiline improves olfaction, including odor detection

• olfactory bulb neurogenesis appears normal

behavior/neurological

behavior/neurological phenotype ( J:199939 )

N • mutants exhibit similar activity and motor ability as wild-type mice

abnormal learning/memory/conditioning ( J:199939 )

• mutants show impaired recollection of an odor after an inter-trial interval of 120 seconds but not 60 or 90 seconds, spending more time sniffing the novel odor than controls, indicating a short-term olfactory memory deficit

• this short-term olfactory memory impairment progressively increases with age

• treatment of 10-11 month old mutants with rasagiline has no effect on the short-term olfactory memory deficit

abnormal olfactory discrimination memory ( J:199939 )

• mutants show impaired odor discrimination in the social odor and non-social odor discrimination tests, however mutants spend a similar time exploring a novel item as wild-type mice indicating visual discrimination between novel and familiar items

• the non-social odor discrimination deficit is age-dependent

• treatment of 10-11 month old mutants with rasagiline improves olfaction, including odor discrimination

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 1		DOID:0060367	OMIM:168601	J:199939