Phenotypes Associated with This Genotype

Genotype
MGI:5529468

• Allelic Composition: Mecp2^tm2.1Meg/Y
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:203745 )

♂ • 12 of 27 mice die by 18.5 weeks

behavior/neurological

abnormal behavior ( J:203745 )

♂ • authors state that mice develop a severe phenotype resembling that of Mecp2^tm1.1Bird

limb grasping ( J:203745 )

♂ • at 6 weeks

impaired coordination ( J:203745 )

♂ • on a rotarod at 15 to 18 weeks

decreased locomotor activity ( J:203745 )

♂ • reduced distance traveled in an open field at 15 to 18 weeks

nervous system

decreased brain weight ( J:203745 )

♂ • at 15 to 18 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:203745