Phenotypes Associated with This Genotype

Genotype
MGI:5529520

• Allelic Composition: Tg(ACTB-THRB*)DSyc/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased grooming behavior ( J:134187 )

• increase is seen during the night time

head bobbing ( J:134187 )

• increase is seen during the night time

hyperactivity ( J:134187 )

increased stereotypic behavior ( J:134187 )

• 2-fold increase in nocturnal stereotypic activities, including grooming, head bopping, and licking

• however, daytime activity levels are normal

• the increase in stereotypic activity and total horizontal distance traveled that is seen in wild-type mice due to administration of methylphenidate, a dopamine reuptake blocker, is attenuated by about 40% and 50% in mutants, respectively

growth/size/body

decreased body weight ( J:134187 )

• mutants weight approximately 10-20% less than controls up to 21 weeks of age

• males show a greater reduction in weight than females, weighing about 22% less than control males at 21-27 weeks of age

• females weigh approximately 9.5% less than control females at 21-27 weeks of age

homeostasis/metabolism

increased thyroxine level ( J:134187 )

• elevation in total T4 and free T4 level

• however, no differences in total T3 levels and serum TSH is normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thyroid hormone resistance syndrome		DOID:11633	OMIM:188570 OMIM:274300	J:134187