Phenotypes Associated with This Genotype

Genotype
MGI:5529521

• Allelic Composition: Tg(ACTB-THRB*)#Syc/0
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal habituation to a new environment ( J:128754 )

• food-restricted males habituate more quickly than wild-type males

• food-restricted females habituate more slowly than wild-type females

impaired learning ( J:128754 )

• mutants are slower to learn to press the lever for food compared to wild-type mice indicating impaired learning of an autoshaping task

• however, mutants exhibit normal behavior on a vigilance task in an operant chamber and on an operant go/no-go task measuring sustained attention and impulsivity

decreased vertical activity ( J:128754 )

♂ • food-restricted males rear less than wild-type mice

increased vertical activity ( J:128754 )

♂ • males, but not females, rear more than wild-type controls

increased locomotor activity ( J:128754 )

♂ • males, but not females, are more active than wild-type controls in open-field activity

hypoactivity in response to feed restriction ( J:128754 )

♂ • food-restricted males exhibit reduced activity in the open-field compared to free-feeding activity levels

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
attention deficit hyperactivity disorder		DOID:1094	OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312	J:128754