Phenotypes Associated with This Genotype

Genotype
MGI:5532925

hm5

• Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm2Wtd
• Genetic Background: involves: 129S1/Sv * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:185289 )

• Background Sensitivity: median survival is 3.5 days, although survival up to 21 days is seen and 13.2% live longer than 7 days; survival is longer than any of the other backgrounds studied, including on the 129S1/Sv or a mixed 129S1/Sv and C57BL/6J background

behavior/neurological

abnormal eating behavior ( J:185289 )

♂ • pups do not feed well and appear generally ill

tremors ( J:185289 )

♂ • mutants that live through the end of the first postnatal week develop abnormal motor behavior, showing tremor and prolonged twisting movements gait, particularly of the hindlimbs

abnormal gait ( J:185289 )

♂ • mutants that live through the end of the first postnatal week develop abnormal motor behavior, showing tremor and prolonged twisting movements gait, particularly of the hindlimbs