Phenotypes Associated with This Genotype

Genotype
MGI:5532944

• Allelic Composition: Flg^ft/Flg^ft
• Genetic Background: STOCK a/a Tmem79^ma Flg^ft/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal skin morphology ( J:204304 )

• skin of 5 day old pups contains a higher population of langerin positive cells

epidermal spongiosis ( J:204304 )

• mild spongiosis is seen by 5 days of age

hyperkeratosis ( J:204304 )

• mild hyperkeratosis is seen by 5 days of age

thin epidermis stratum granulosum ( J:204304 )

• hypogranulosis

acanthosis ( J:204304 )

• seen by 5 days of age

thick epidermis ( J:204304 )

• seen by 5 days of age

flaky skin ( J:204304 )

• on the tail

scaly skin ( J:204304 )

• presence of scales on the tail skin

• however mice do not exhibit abnormal corneodesmosomal desquamation

abnormal skin physiology ( J:204304 )

• lymphocytic exocytosis in 5 day old skin

• marker analysis indicates abnormal differentiation state of the epidermis and hyperproliferation

dermatitis ( J:204304 )

• reactive inflammatory epidermitis by 5 days of age

homeostasis/metabolism

epidermal spongiosis ( J:204304 )

• mild spongiosis is seen by 5 days of age

abnormal cytokine level ( J:204304 )

• skin of 5 day old pups shows increased levels of proinflammatory cytokines, including Il4, Il13, Il1beta, and Tslp

immune system

abnormal cytokine level ( J:204304 )

• skin of 5 day old pups shows increased levels of proinflammatory cytokines, including Il4, Il13, Il1beta, and Tslp

dermatitis ( J:204304 )

• reactive inflammatory epidermitis by 5 days of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atopic dermatitis 2		DOID:0110098	OMIM:605803	J:204304