Phenotypes Associated with This Genotype

Genotype
MGI:5538526

• Allelic Composition: Mecp2^tm3Meg/Y
• Genetic Background: B6.129-Mecp2^tm3Meg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:204723 )

♂ • mice treated with pentylenetetrazol (PTZ) exhibit earlier onset time and frequency of tonic-clonic seizures compared with wild-type mice

limb grasping ( J:204723 )

♂

impaired coordination ( J:204723 )

♂ • on a rotarod

nervous system

increased susceptibility to pharmacologically induced seizures ( J:204723 )

♂ • mice treated with pentylenetetrazol (PTZ) exhibit earlier onset time and frequency of tonic-clonic seizures compared with wild-type mice

decreased brain weight ( J:204723 )

♂

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:204723