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Phenotypes Associated with This Genotype
Genotype
MGI:5538574
Allelic
Composition		 Oprm1tm1Kff/Oprm1tm1Kff
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1tm1Kff mutation (1 available); any Oprm1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal social investigation ( J:204731 )
• males do not show a change in social exploratory activity when exposed to playback of female ultrasonic vocalizations unlike wild-type males that exhibit an increase of exploratory activity
• males however, exhibit normal behavior in the auditory cued-fear conditioning task

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
autism spectrum disorder DOID:0060041 J:204731

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory