Phenotypes Associated with This Genotype

Genotype
MGI:5538583

• Allelic Composition: Tg(MMTV-Erbb2)NK1Mul/0
• Genetic Background: FVB/N-Tg(MMTV-Erbb2)NK1Mul

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:67457 )

♀ • about 20% of mutants develop mammary tumors by the 25th week of age, and by the 30th week, tumor incidence increases to 83%

♀ • high dose of flaxseed oil (with a an omega6:omega3 fatty acid ratio of about 1) results in some delay in the growth of mammary tumors, however low and mid doses with omega6:omega3 ratios of 7.7 and 3.1 enhance tumor development

♀ • melatonin treatment delays the appearance of palpable tumors

♀ • combination of both flaxseed oil and melatonin results in a slight delay of tumor development, similar that seen with melatonin only

integument

increased mammary gland tumor incidence ( J:67457 )

♀ • about 20% of mutants develop mammary tumors by the 25th week of age, and by the 30th week, tumor incidence increases to 83%

♀ • high dose of flaxseed oil (with a an omega6:omega3 fatty acid ratio of about 1) results in some delay in the growth of mammary tumors, however low and mid doses with omega6:omega3 ratios of 7.7 and 3.1 enhance tumor development

♀ • melatonin treatment delays the appearance of palpable tumors

♀ • combination of both flaxseed oil and melatonin results in a slight delay of tumor development, similar that seen with melatonin only

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:67457 )

♀ • about 20% of mutants develop mammary tumors by the 25th week of age, and by the 30th week, tumor incidence increases to 83%

♀ • high dose of flaxseed oil (with a an omega6:omega3 fatty acid ratio of about 1) results in some delay in the growth of mammary tumors, however low and mid doses with omega6:omega3 ratios of 7.7 and 3.1 enhance tumor development

♀ • melatonin treatment delays the appearance of palpable tumors

♀ • combination of both flaxseed oil and melatonin results in a slight delay of tumor development, similar that seen with melatonin only

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:67457