Phenotypes Associated with This Genotype

Genotype
MGI:5543815

cn9

• Allelic Composition: Gt(ROSA)26Sor^{tm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm}/Gt(ROSA)26Sor⁺; Tg(Fabp7-cre,-lacZ)3Gtm/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:204469 )

• mice are born in Mendelian ratios but do not survive beyond 8 to 10 weeks

digestive/alimentary system

abnormal digestive system morphology ( J:204469 )

• abnormal alimentary canal, ranging from severely swollen stomachs to blackened hindguts

abnormal hindgut morphology ( J:204469 )

• blackened hindguts in some mice

enlarged stomach ( J:204469 )

• severely swollen in some mice

abnormal digestive system physiology ( J:204469 )

• mice become malnourished

nervous system

nervous system phenotype ( J:204469 )

N • cell proliferation and survival are normal in the cerebellum

increased astrocyte number ( J:204469 )

• GFAP+ and S100B+ without a change in proliferation or apoptosis rates