Phenotypes Associated with This Genotype

Genotype
MGI:5543906

• Allelic Composition: Snca^tm1Rosl/Snca^tm1Rosl; Tg(SNCA*A30P)192Rwm/0
• Genetic Background: B6.Cg-Snca^tm1Rosl Tg(SNCA*A30P)#Rwm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:201961 )

N • aged mutants do not exhibit catecholaminergic neuron loss or alpha-synuclein neuropathology and show normal novelty-induced activity, forepaw stride length, activity on the accelerating rotarod, anxiety, immobility times in the tail suspension test, circadian rhythms, and spontaneous alternation in the T-maze

increased locomotor activity ( J:201961 )

• mutants are more active in wheel running during the dark phase, however activity in locomotor cages is normal

homeostasis/metabolism

decreased dopamine level ( J:201961 )

• electrically evoked release of dopamine is reduced in the caudate putamen, but not in the nucleus accumbens compared to single homozygous Snca^tm1Rosl mutants, and show normal norepinephrine release in the stria terminalis

nervous system

abnormal nervous system physiology ( J:201961 )

• mutants are sensitive to the dopaminergic neurotoxin, MPTP, showing nigral and striatal damage, unlike single homozygous Snca^tm1Rosl mutants which show resistance

digestive/alimentary system

digestive/alimentary phenotype ( J:201961 )

N • mutants appear to have normal gastrointestinal function as shown by normal stool water content, stool dry weight and stool frequency

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 1		DOID:0060367	OMIM:168601	J:201961