Analysis Tools
endocrine/exocrine glands
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• 3 of 18 mutants exhibit abnormal tumor-like ovaries at 8 weeks of age, with tumors showing some, but not all the characteristics of the mature teratomas
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• 5 of 18 mutants develop ovarian teratomas at 2-6 months of age, some of which appear malignant; mice that develop teratomas show high transgene expression
• teratomas are characterized by areas of invasive, undifferentiated cells and inclusion cysts lined with ciliated cells reminiscent of oviductal or respiratory epithelium
• 3 of the tumors contain squamous cell-lined cysts filled with keratin and well-to-moderately differentiated invasive squamous cells and nervous tissue-like areas
• fat, blood-filled spaces, calcified bone and cartilage formation, and thyroid gland-like structures are seen in some teratomas
• by 6 months of age, teratomas are about 10 times the size of a normal ovary, do not show normal follicular or ovarian structures, and contain many highly proliferative epithelium-lined inclusion cysts
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ovary cyst
(
J:200783
)
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• mutants develop ovarian inclusion cysts; mice that only develop inclusion cysts show low transgene expression
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reproductive system
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• 3 of 18 mutants exhibit abnormal tumor-like ovaries at 8 weeks of age, with tumors showing some, but not all the characteristics of the mature teratomas
|
|
|
• 5 of 18 mutants develop ovarian teratomas at 2-6 months of age, some of which appear malignant; mice that develop teratomas show high transgene expression
• teratomas are characterized by areas of invasive, undifferentiated cells and inclusion cysts lined with ciliated cells reminiscent of oviductal or respiratory epithelium
• 3 of the tumors contain squamous cell-lined cysts filled with keratin and well-to-moderately differentiated invasive squamous cells and nervous tissue-like areas
• fat, blood-filled spaces, calcified bone and cartilage formation, and thyroid gland-like structures are seen in some teratomas
• by 6 months of age, teratomas are about 10 times the size of a normal ovary, do not show normal follicular or ovarian structures, and contain many highly proliferative epithelium-lined inclusion cysts
|
ovary cyst
(
J:200783
)
|
|
• mutants develop ovarian inclusion cysts; mice that only develop inclusion cysts show low transgene expression
|
neoplasm
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|
• 3 of 18 mutants exhibit abnormal tumor-like ovaries at 8 weeks of age, with tumors showing some, but not all the characteristics of the mature teratomas
|
|
|
• 5 of 18 mutants develop ovarian teratomas at 2-6 months of age, some of which appear malignant; mice that develop teratomas show high transgene expression
• teratomas are characterized by areas of invasive, undifferentiated cells and inclusion cysts lined with ciliated cells reminiscent of oviductal or respiratory epithelium
• 3 of the tumors contain squamous cell-lined cysts filled with keratin and well-to-moderately differentiated invasive squamous cells and nervous tissue-like areas
• fat, blood-filled spaces, calcified bone and cartilage formation, and thyroid gland-like structures are seen in some teratomas
• by 6 months of age, teratomas are about 10 times the size of a normal ovary, do not show normal follicular or ovarian structures, and contain many highly proliferative epithelium-lined inclusion cysts
|
growth/size/body
ovary cyst
(
J:200783
)
|
|
• mutants develop ovarian inclusion cysts; mice that only develop inclusion cysts show low transgene expression
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| dermoid cyst of ovary | DOID:5117 |
OMIM:166950 |
J:200783 | |
