Phenotypes Associated with This Genotype

Genotype
MGI:5544078

• Allelic Composition: Tg(Snca-SNCA/GFP)#Jyl/Tg(Snca-SNCA/GFP)#Jyl
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal response to novel odor ( J:197984 )

♂ • in an odor discrimination test, 7 and 12 month old males spend less time exploring a new smell than controls; a similar tendency is seen for females but it does not reach significance

impaired coordination ( J:197984 )

♀ • 12 month old females, but not males, perform worse than controls on the rotarod test

decreased locomotor activity ( J:197984 )

♀ • while under normal conditions, mutants exhibit normal locomotor activity, 7 month old females, but not males, administered with amphetamine exhibit less ambulatory movement

nervous system

alpha-synuclein inclusion body ( J:197984 )

• aggregated alpha-synuclein is detected in 15 month old mutant brains

abnormal synaptic dopamine release ( J:197984 )

• 3 and 12 month old mutants exhibit altered dopamine release and reuptake patterns; the peak amplitude, or amount, of dopamine release induced by depolarization with a fixed amount of locally applied KCl is reduced

• dopamine uptake is reduced at 3 and 12 months of age and release rate is lower at 3 months of age, with a trend for reduction at 12 months of age

• the total dopamine load is reduced at 12 months of age indicating reduced dopamine transmission in the striatum

• however, dopaminergic neuron loss is not seen in 3 or 12 month old mutants

taste/olfaction

impaired olfaction ( J:197984 )

♂ • in an odor discrimination test, 7 and 12 month old males spend less time exploring a new smell than controls; a similar tendency is seen for females but it does not reach significance

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease		DOID:14330	OMIM:PS168600	J:197984