Analysis Tools
vision/eye
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• at 9 weeks of age small hyper-autofluorescence spots are distributed uniformly over the fundus
• at 18 weeks of age hyper-autofluorescence spots form larger patches of heterogenous size
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• progressive arteriolar narrowing is seen between 9 and 18 weeks of age
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• progressive reduction in the number of photoreceptors in the outer nuclear layer from 2 to 18 weeks of age
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• slow progressive photoreceptor degeneration
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• mixed rod-cone responses are lower and progressively decrease over time
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• decreases in photopic cone responses are slower than those in rod or mixed rod-cone responses
• decreases are seen after 15 weeks of age
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• rod-specific b-wave peaks are depressed or extinguished in mice between 6 and 18 weeks of age
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nervous system
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• progressive reduction in the number of photoreceptors in the outer nuclear layer from 2 to 18 weeks of age
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• slow progressive photoreceptor degeneration
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cardiovascular system
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• progressive arteriolar narrowing is seen between 9 and 18 weeks of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| retinitis pigmentosa 40 | DOID:0110375 |
OMIM:613801 |
J:200898 | |
