Phenotypes Associated with This Genotype

Genotype
MGI:5544476

• Allelic Composition: Pde6b^rd1/Pde6b^rd1
• Genetic Background: involves: C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal optic disk morphology ( J:101336 )

• pale at 3.5 weeks of age

vision/eye

abnormal ocular fundus morphology ( J:101336 )

• patchy, pigmented appearance at 3.5 weeks of age

abnormal optic disk morphology ( J:101336 )

• pale at 3.5 weeks of age

thin retina outer nuclear layer ( J:101336 )

• only a single layer of cells is present at 3.5 weeks of age

retina degeneration ( J:101336 )

• degeneration is accelerated compared to mice homozygous for Pde6b^atrd2

decreased visual acuity ( J:101336 )

• fail to respond in a visual tracking drum assay at 3.5, 6 and 10 weeks of age

blindness ( J:101336 )

• effectively blind by 3.5 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa 40		DOID:0110375	OMIM:613801	J:101336