Phenotypes Associated with This Genotype

Genotype
MGI:5547378

cn22

• Allelic Composition: Nr4a2^tm1.1Pcn/Nr4a2^tm1.1Pcn; Tg(Lck-cre)1Jtak/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:205658 )

• more than half of mice

immune system

immune system phenotype ( J:205658 )

N • surviving mice exhibit no auto-immune disease symptoms up to 4 months of age

N • mice exhibit normal numbers of regulatory T cells in the thymus and spleen

increased susceptibility to induced colitis ( J:205658 )

• DSS-treated mice exhibit accelerated body weight loss, severe intestinal inflammation, increased Th1 cells and attenuated increase of regulatory T cells in the colon and cecum lamina propria compared with control mice

abnormal T-helper 1 cell differentiation ( J:205658 )

• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions

abnormal T-helper 17 cell differentiation ( J:205658 )

• reduced under Th17-skewing conditions

increased CD4-positive, alpha-beta T cell number ( J:205658 )

• CD44highCD62Llow-activated and IFN-gamma CD4+ T cells

increased T-helper 1 cell number ( J:205658 )

• in DSS-treated mice

abnormal regulatory T cell morphology ( J:205658 )

• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions

decreased regulatory T cell number ( J:205658 )

• in DSS-treated mice

digestive/alimentary system

increased susceptibility to induced colitis ( J:205658 )

• DSS-treated mice exhibit accelerated body weight loss, severe intestinal inflammation, increased Th1 cells and attenuated increase of regulatory T cells in the colon and cecum lamina propria compared with control mice

growth/size/body

increased susceptibility to weight loss ( J:205658 )

• accelerated in DSS-treated mice

hematopoietic system

abnormal T-helper 1 cell differentiation ( J:205658 )

• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions

abnormal T-helper 17 cell differentiation ( J:205658 )

• reduced under Th17-skewing conditions

increased CD4-positive, alpha-beta T cell number ( J:205658 )

• CD44highCD62Llow-activated and IFN-gamma CD4+ T cells

increased T-helper 1 cell number ( J:205658 )

• in DSS-treated mice

abnormal regulatory T cell morphology ( J:205658 )

• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions

decreased regulatory T cell number ( J:205658 )

• in DSS-treated mice