Phenotypes Associated with This Genotype

Genotype
MGI:5547758

• Allelic Composition: Tg(Utg-TAg)7736Fjd/?
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:70785 )

• succumb at 16-20 weeks

respiratory system

increased lung adenocarcinoma incidence ( J:70785 )

• mutants develop multifocal pulmonary adenocarcinoma of the lung and succumb at 16-20 weeks of age

• bronchiolar epithelium shows areas of hyperplasia by 2 months of age, tumor foci are seen at 3 months and majority of lung is composed of transformed cells 4 weeks later

bronchiolar epithelial hyperplasia ( J:70785 )

• areas of hyperplasia of the bronchiolar epithelium are seen by 2 months of age

neoplasm

increased lung adenocarcinoma incidence ( J:70785 )

• mutants develop multifocal pulmonary adenocarcinoma of the lung and succumb at 16-20 weeks of age

• bronchiolar epithelium shows areas of hyperplasia by 2 months of age, tumor foci are seen at 3 months and majority of lung is composed of transformed cells 4 weeks later

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:70785