Phenotypes Associated with This Genotype

Genotype
MGI:5548175

cx27

• Allelic Composition: Gdf15^tm1Sjl/Gdf15^tm1Sjl; Lepr^db/Lepr^db
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased fluid intake ( J:202996 )

♂ • water intake and urine output are increased at week 9 compared to single Lepr mutants

increased food intake ( J:202996 )

♂ • food intake is increased over single Gdf15 mutants but is similar to single Lepr mutants

cardiovascular system

increased heart weight ( J:202996 )

♂ • increase in heart weight compared to controls, including that in single Lepr mutants

growth/size/body

increased heart weight ( J:202996 )

♂ • increase in heart weight compared to controls, including that in single Lepr mutants

increased body weight ( J:202996 )

♂ • body weight is increased over nondiabetic single Gdf15 mutants but is similar to single Lepr mutants

increased kidney weight ( J:202996 )

♂ • kidney weight is increased to a similar extent as in single Lepr mutants

increased liver weight ( J:202996 )

♂ • liver weight is increased to a similar extent as in single Lepr mutants

homeostasis/metabolism

increased circulating creatinine level ( J:202996 )

♂ • increase in serum creatinine levels compared to controls, including that in single Lepr mutants

hyperglycemia ( J:202996 )

♂ • nonfasting blood glucose and HbA1c are higher in double mutants than in single Lepr mutants at the final time point of 18 weeks but are similar at earlier time points but higher than in single Gdf15 mutants

increased urine glucose level ( J:202996 )

♂ • urinary glucose loss is higher than in single Lepr mutants at week 14

increased cholesterol level ( J:202996 )

♂ • similar increase in cholesterol level as in single Lepr mutants

increased circulating HDL cholesterol level ( J:202996 )

♂ • similar increase in HDL levels as in single Lepr mutants

albuminuria ( J:202996 )

♂ • similar increase in urinary albumin excretion as in single Lepr mutants

liver/biliary system

increased liver weight ( J:202996 )

♂ • liver weight is increased to a similar extent as in single Lepr mutants

renal/urinary system

increased urine glucose level ( J:202996 )

♂ • urinary glucose loss is higher than in single Lepr mutants at week 14

albuminuria ( J:202996 )

♂ • similar increase in urinary albumin excretion as in single Lepr mutants

abnormal kidney morphology ( J:202996 )

♂ • marker analysis indicates that double mutants show an increase in renal damage and in interstitial and tubular damage in the kidney compared to single Lepr mutants

increased kidney weight ( J:202996 )

♂ • kidney weight is increased to a similar extent as in single Lepr mutants

glomerulosclerosis ( J:202996 )

♂ • glomerulosclerosis is similar as in single Lepr mutants

polyuria ( J:202996 )

♂ • water intake and urine output are increased at week 9 compared to single Lepr mutants