Phenotypes Associated with This Genotype

Genotype
MGI:5548208

• Allelic Composition: Tg(Vav1-ERG)#Jpim/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased leukemia incidence ( J:174808 , J:203438 )

• all mice develop acute leukemia (J:174808)

• all other mice that do not have T-ALL develop myeloid leukemia, showing massive infiltration of leukemic blasts into the bone marrow, the spleen, and the liver, anemia, and thrombocytopenia (J:203438)

• leukemic cells are lineage negative and c-Kit+Sca-1-CD150+, characteristic of megakaryocyte-erythroid progenitors and gene expression and binding analysis show that these leukemias show a transcriptional program similar to human acute myeloid leukemia (J:203438)

• the Pim1 inhibitor SGI-1776 inhibits leukemia cell growth and induces apoptosis in these cells (J:203438)

increased acute lymphoblastic leukemia incidence ( J:174808 , J:203438 )

• approximately 30% of leukemias are characterized as T-acute lymphoblastic leukemia (T-ALL) (J:174808)

• immunophenotype of the T-ALL blasts is cKit-CD3+CD8+CD4- (J:174808)

• about 30% of mice develop T-ALL (J:203438)

mortality/aging

premature death ( J:174808 , J:203438 )

• all mice that develop T-ALL die by 7 months of age with a median survival age of 20 weeks (J:174808)

• all mice that do not develop and die from T-ALL, die from myeloid leukemia by 5 months of age (J:203438)

hematopoietic system

abnormal thymus morphology ( J:174808 )

• dense infiltration of thymus with lymphoblasts and almost complete disorganization of the tissue architecture

enlarged thymus ( J:174808 )

enlarged spleen ( J:174808 )

immune system

abnormal thymus morphology ( J:174808 )

• dense infiltration of thymus with lymphoblasts and almost complete disorganization of the tissue architecture

enlarged thymus ( J:174808 )

enlarged spleen ( J:174808 )

endocrine/exocrine glands

abnormal thymus morphology ( J:174808 )

• dense infiltration of thymus with lymphoblasts and almost complete disorganization of the tissue architecture

enlarged thymus ( J:174808 )

growth/size/body

enlarged spleen ( J:174808 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute myeloid leukemia		DOID:9119	OMIM:601626	J:203438